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HIV drugs appear to have worse side-effects on women, compared to men – experts

Some studies in Kenya show women gain fat that is concentrated in the limbs and trunk.

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by JOHN MUCHANGI

Health27 February 2025 - 22:34
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In Summary


  • Prof Elizabeth Bukusi, a chief research officer at the Kenya Medical Research Institute (Kemri) said the goal is to ensure people take the best drugs that have fewer side effects. 

The current drug regimen are efficacious but there is need more data on side-effects, experts say.

Kenyan experts are calling for more studies on the effects of different HIV medications on women.

They said some medicines cause more adverse different side effects in women than in men.

Of major concern is weight gain. In addition to women being more likely to experience weight gain with ARV initiation, the pattern of weight gain differs between men and women.

Some studies show women gain fat that is concentrated in the limbs and trunk.

Dr Loice Ombajo, head of infectious disease unit at Kenyatta National Hospital, noted that women are more likely to abandon treatment because of adverse side-effects.

“A patient was put on antiretroviral therapy in 2021, but by last year had gained 40 kilogrammes. She says I can’t find a dress that fits me. That’s the reality we have to face.

We have to think of how do we transition women facing weight gain,” she said.

Dr Ombajo spoke at the second edition of the African Workshop on Women & HIV in Nairobi on Thursday.

The meeting explored changes that will provide a better quality of life for women living with HIV and reduce HIV transmissions in the region.

Dr Ombajo said 76 per cent of all HIV positive women in the world live in subsaharan Africa.

“Women are also disproportionately affected in Kenya,” she said.

According to the Kenya HIV Estimates 2023, out of the 1.4 million Kenyans living with HIV, approximately 890,747 were women.

“Current drug regimen are efficacious but we need more data on side-effects,” Dr Ombajo said.

Prof Elizabeth Bukusi, a chief research officer at the Kenya Medical Research Institute (Kemri), said the goal is to ensure people take the best drugs that have fewer side effects.

“No matter what you take, they always will have some side effects. The question is can we find those that we can minimise the side effects to make it easier for people to be able to take them,” she told The Star.

She also said it is better to focus on men as well.

“Because the men play an important role. They're partners in this, because a woman who can't disclose her status to her husband will have difficulty in staying on treatment.

And so getting men to walk alongside, because the empowerment of men will enable them to empower the women to be able to look after themselves,” she said .

Currently, an estimated 1.378 million Kenyans are living with HIV, with 97 per cent receiving treatment through a network of 3,752 treatment sites, according to the National Syndemic Diseases Control Council (NSDCC).

Last year on December 1, Dr. Ruth Laibon-Masha, CEO of the NSDCC, revealed that Kenya’s national HIV prevalence rate of 3.3 per cent rises to 18.7 per cent among people who inject drugs.

In 2023, about 20,478 Kenyans died due to AIDS-related causes, including 2,607 children aged 0-14.

However, NSDCC says that Kenya is on track to meet the UNAIDS 95-95-95 targets by 2025—aiming for 95 per cent of people living with HIV to know their status, 95 per cent of those diagnosed to access treatment, and 95 per cent of those on treatment to achieve viral suppression.

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