POIS is a rare condition characterized by multisystem symptoms with unclear aetiology.
Symptoms of post-orgasmic illness syndrome may last from one to seven days.
The prevalence of POIS is unknown and difficult to determine, as it is likely that many affected individuals do not seek medical attention.
Treatment recommendations have included antihistamines, benzodiazepines, selective serotonin reuptake inhibitors, and CNS stimulants.
