A section of Ngong Road will be closed on Sunday to allow the erection of a footbridge.
In a public notice on Friday by Kura, the road will be closed from 9 am to 6 pm.
"The Kenya Urban Roads Authority wishes to notify the general public that a section of Ngong Road at the Kenyatta National Hospital stage will be closed off on Sunday to allow for the erection of the steel deck footbridge crossing," reads the notice by Kura's DG Silas Kinoti.
The steel deck crossing is part of the footbridge being constructed at that location.
To allow smooth flow of traffic, motorists heading to the Nairobi CBD will be diverted to Valley Road while those heading to Mombasa Road will be diverted to Mbagathi Way.
In addition, Kura has urged motorists and pedestrians to be careful when approaching the section under construction.
They have also been advised to strictly follow diversions as guided by the traffic signs and the traffic marshals on site.
"We request the public to be patient as we work to enhance pedestrian safety and urban mobility," reads the notice.