All six people on board a medical plane that crashed in a Philadelphia neighbourhood on Friday night were killed, including a mother and her daughter, according to the mayor's office
Philadelphia Mayor Cherelle Parker adds that "many people on the ground" were injured as homes and fires in the areas were ablaze in the aftermath
The medical transport plane was taking the girl - who had been receiving care in the US for a life-threatening condition - back to Tijuana, Mexico. Four crew members were also on board
Flight logs show the plane was in the air "for only a minute before it crashed"
In an audio recording obtained by CBS News, the BBC's US partner, an air traffic controller can be heard saying they're "not exactly sure what happened"
A small plane with six aboard has crashed into several buildings in north-east Philadelphia, setting homes and vehicles ablaze, and injuring people on the ground.
The jet was on a medical transport mission on Friday evening and was carrying four crew members, a child patient and the patient's escort, Jet Rescue Air Ambulance, the medical aircraft company, told Reuters and other US media.
"We know that there will be loss," Pennsylvania Gov Josh Shapiro said during a news conference at the scene of the crash, calling it an "awful aviation disaster".
Emergency crews rushed to the scene during evening rush hour, as residents crowded streets that were littered with fiery debris and pieces of the aircraft. Many described a chaotic scene with injured people running and a neighbourhood block on fire.
Philadelphia Mayor Cherelle Parker said city officials do not know the number of fatalities, but the city is "asking for prayers for anyone and everyone that may have been affected".
"If you see debris, call 911, don't touch anything," she told city residents.
The crash happened just blocks from the Roosevelt Mall, a three-story shopping centre in a densely populated part of the Pennsylvania city.
The area where the crash occurred is filled with terraced housing and shops.
Disturbing videos of the incident online show the plane coming down quickly and sparking a huge fireball that rocketed into the sky.
